New research highlights side effects of coronavirus vaccination

Illustration of the COVID-19 coronavirus vaccine

Two new studies have looked at side effects of COVID-19 vaccines. The first study found that common side effects such as redness, pain, and fatigue were more prevalent, with women between the ages of 25 and 35 and those with a history of COVID-19 experiencing side effects more often. The second study found that 30% of menstruating women reported changes in their menstrual cycles after vaccination, although causation was not confirmed.

After a brief period Covid-19 Vaccinations Individuals in Denmark have reported mild side effects such as general discomfort, elevated body temperature, and fatigue. Severe adverse reactions such as facial paralysis and allergic responses are rare. In addition, 30% of menstruating women reported changes in their menstrual cycles.

Aarhus University It recently published two studies looking at side effects of COVID-19 vaccines.

Both studies are based on the Danish language BiCoVac CohortThis makes it possible to conduct studies on a large Danish population. One study looked at severe side effects of COVID-19 vaccination.

The most common side effects after the first small prick on the shoulder are: Redness and pain at the injection site, which 20% of people suffer from. After the second and third strikes exhaustion It is the most frequently reported side effect – reported by 22% and 14% of people, respectively.

The study was published in the journal Serum. The study found that common side effects such as malaise, fever and fatigue are among the most common in Denmark after vaccination against COVID-19. More serious side effects such as facial paralysis and allergic reactions are not common.

Torp Hansen and Christina Bisgaard Jensen

Research Assistant Christopher Torp-Hansen and Ph.D. Student Christina Bisgaard Jensen published a study on side effects after vaccination against the Corona virus. Credit: Simone Perial Fishel/AU

“Women, people ages 25-35, and people who had COVID-19 before vaccination reported experiencing side effects more frequently than men, older adults, and people who had not previously had COVID-19,” says Christopher Torp. Hansen, first author of the study and a research assistant in the Department of Public Health.

The results also show that severe side effects vary depending on which vaccine is given.

People vaccinated with the AstraZeneca vaccine reported more side effects after the first dose than people vaccinated with other vaccines.

People who received the Moderna vaccine reported more side effects after the second and third doses than people who received the vaccine from Pfizer-BioNTech.

Several factors play a role in reporting menstrual changes

The second study showed that 30% of menstruating women reported changes in their menstrual cycle after vaccination against Covid-19.

The researchers examined factors that could play a role in those changes, and discovered that commonly known causes of menstrual changes, such as stress, age, and smoking, were related to the menstrual changes reported after vaccination against Covid-19.

“We also found that women who were concerned about the COVID-19 vaccine, who had a severe COVID-19 infection or who reported having had multiple reactions to the vaccine were more likely to report menstrual changes after vaccination,” says Christina Bisgaard-Jensen. . , PhD student in the Department of Public Health. She is the first author of the study, which was just published in the scientific journal human reproduction.

“Changes in the menstrual cycle are not uncommon, and we cannot rule out that for some people, menstrual changes occurred randomly in connection with vaccination,” says Christina Bisgaard Jensen. Determine the direct relationship between the Covid1-9 vaccine and reported menstrual changes.

“More studies are needed to establish causal relationships and clinical significance of self-reported menstrual changes,” she says.

Reference: “Immediate adverse reactions after coronavirus vaccination among Danish citizens aged 16–65 years” by K. Torp Hansen, F. Kusk Povlsen, B. Hammer Bech, S. Nygaard Hansen, C. Ulrikka Rask, P Fink, T. Jorgensen, H. Nielsen, T. Meinertz Dantoft, S. Mary Thyson, and Dr. Ritter, June 23, 2023, Available here. Serum.
DOI: 10.1016/j.vaccine.2023.06.069

“Prevalence and risk factors for self-reported menstrual changes after coronavirus vaccination: a Danish cohort study” by C Bisgaard Jensen, P Hammer Beck, S Nygaard Hansen, C Ulrika Rask, P Fink, H Nielsen, T Meinertz Dantoft, S Marie Thysen Woody Ritter, July 12, 2023, Available Here. human reproduction.
doi: 10.1093/hmreb/met144

Both studies were funded by TrygFonden.

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