Viagra may prevent Alzheimer’s – study — RT World News
An erectile dysfunction drug could prevent cognitive decline, a new study suggests
Sildenafil, the generic name for Viagra, may not only treat erectile dysfunction and pulmonary arterial hypertension, but also prevent cognitive decline, according to researchers. research It was published by the Genome Center at Cleveland Clinic earlier this month.
The authors of the study, published in the journal Alzheimer's Disease on March 1, found that those who took sildenafil were 30% to 54% less likely to develop Alzheimer's disease. The researchers used real-world patient data from the MarketScan Medicare Supplement Database (2012-2017) and the Clinformatics Database (2007-2020) to reach the conclusion.
The research focused on those taking sildenafil or four similar drugs, including bumetanide, furosemide, spironolactone, and nifedipine. Comparators are drug products already on the market, or new drugs in development, including placebo versions. The sex, age, race, and comorbidities of the patients were taken into account.
The study concluded that the use of sildenafil was associated with a lower risk of developing Alzheimer's disease compared to control medications. The results also showed that the drug activates genes in nerve cells that affect cell growth, improves brain function and reduces the risk of inflammation.
“We used artificial intelligence to combine data across multiple domains that all pointed to the potential of sildenafil against this devastating neurological disease.” Feixiong Cheng, director of the Genome Center at the Cleveland Clinic, who led the study, said:
Similar conclusions about sildenafil were reached by researchers from University College London earlier this year. The study, published in the Journal of Neuroscience last month, included nearly 270,000 men who were diagnosed with erectile dysfunction and did not have cognitive problems at the beginning of the research work. Those who took the medications were 18% less likely to develop the condition causing dementia.
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